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Probiotics
13 May 2022
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What do various Whole Food Plant-Based doctors say about probiotics?
Dr Sean Spencer

Are probiotics risk free? A lecture presentation by Dr Sean Spencer (Physician Scientist at Stanford) sheds some light:

(2024, 85 mins) Feeding Your Microbiome: Dietary Strategies for Wellness and Disease Prevention

The observations on microbiome recovery & immunotherapy for melanoma are surprising — can probiotics impair our microbiome and immune system?
49:44 (Overview) Probiotics May Be Associated with Risk
51:39 Antibiotics & Microbiome Recovery with & without Probiotics
54:29 Probiotics & Immunotherapy for Melanoma
56:25 Dr Sean Spencer's recommendations for Prebiotics, Probiotics, Post-biotics & Synbiotics.
59:21 next topic

(2025, 79 mins) Probiotic Pills: Usually Harmful, Sometimes Fatal | Viva Longevity

An interview with Dr Sean Spencer by Viva Longevity.

Dr Neal Barnard
(37 mins, 2020) Fermented Foods and Probiotics

At offset 1:52, Dr Barnard is asked, "What is Dr Barnard's opinion on probiotics, either supplements or through fermented veggies such as sauerkraut or kimchi?"

Dr Barnard's reply, "Don't waste your time." He cites a study in which people who had taken antibiotics were divided into two groups; those who took probiotics "did not replenish their gut bacteria as well as people who just let nature take its course."

Dr Angie Sadeghi

Dr Angie Sadeghi says:

Dr. Sadeghi supported her statement by noting that she does not go out of her way to eat fermented foods. Until there are more studies to prove the benefits of ingested probiotics, you won’t find her popping any pills or spooning “gut-friendly” yogurt—nor will she recommend these to her patients.

(32 mins, 2019) Tips for Fiber Challenged People

This is an excellent interview. Insightful. At offset 25:32, Dr Sadeghi explains why she's not a fan of probiotics, citing this research paper in Cell (2018).

Also see this FaceBook post by DR Danielle Belardo. Excerpt:

"We used to think that although probiotics may not be helpful, they weren’t harmful either. But Dr. Sadeghi explains how this mindset has shifted. In a study published in Cell, researchers wanted to evaluate if probiotics would help recolonize the gut of individuals taking antibiotics. Participants underwent endoscopy and colonoscopy to observe changes to the gut microbiome before and following antibiotic treatment. They randomized participants to either no probiotics, or an 11-strain probiotic over a 4-week period. So what did they find? The group who took the probiotics did WORSE than those who didn’t: probiotic colonization actually prevented the gene expression and microbiome from returning to normal pre-antibiotic configurations for months afterward."

Dr Alan Desmond

At offset 14:33 of this video, Dr Alan Desmond (WFPB gastroenterologist from UK) explains that prebiotics (eating a variety of plants in their whole form) is far more effective than probiotics. Our focus should be on prebiotics. In other words, diversity of plants: whole grains, beans, fruits, veggies, nuts & seeds, herbs & spices.

Dr Michael Klaper

Probiotics Principles (updated 2017) by Dr Klaper

(5 mins, 2022) Probiotics — Do We Need Them?

Dr Klaper mentions that his own views on probiotics changed during his career as a physician. He now concurs with other docs like Dr Greger and Dr Bulsiewicz that prebiotics ((basically fiber-rich & resistant-starch rich foods) are far more important than probiotics.

(7 mins, 2020) Antibiotics - Gut Health & Should You Take Probiotics?
(2012) Boosting Good Bacteria in the Colon Without Probiotics

(1 min) Transcript.

(2012) Tipping Firmicutes to Bacteroidetes

(2 mins) Transcript.

(3 mins, 2019) Should We Take Probiotics?
(2019) Prebiotics — Tending Our Inner Garden

(6 mins) Transcript.

(2017) Culture Shock — Questioning the Efficacy and Safety of Probiotics

(5 mins) Transcript. Dr Greger's summary: "In certain medical conditions, probiotic supplements may actually make things worse."

(2013) Preventing & Treating Diarrhea with Probiotics

(4 mins) Transcript. Dr Greger's summary: "Probiotics may help prevent antibiotic-associated diarrhea, and appear to speed recovery from acute gastroenteritis."

(2013) Preventing the Common Cold with Probiotics?

(4 mins) Transcript. Dr Greger's summary: "Though prebiotics may be preferable, probiotics may reduce the risk of upper respiratory tract infections."

(2013) Should Probiotics Be Taken Before, During, or After Meals?

(2 mins) Transcript. Dr Greger's summary: "Proper timing of probiotic supplements may improve their survival."

(2013) Gut Feelings: Probiotics & Mental Health

(5 mins) Transcript. Dr Greger's summary: "We've known our mental state can affect our gut flora, but might our good bacteria be affecting our mental state?"

Dr Will Bulsiewicz

Excerpt from this CNET article from 2020:

According to Dr. Bulsiewicz, even though probiotic use is widespread and relatively safe, he is uncertain that most supplements actually do what they claim.

"The bottom line is that you want and should expect results from your probiotic. Unfortunately, many do not get results, and are left confused and frustrated that they spent so much money. To increase the odds of success with a probiotic, you should opt for the strain and quantity that has been proven in study to work for whatever medical condition you are trying to address," Dr. Bulsiewicz says.

An excerpt from offset 46:00 of this podcast interview:

… let's pretend hypothetically that you're in my clinic. Jonathan, you're my patient. Okay. To me, I want to start with getting at the root cause of the problem, and that starts with diet and lifestyle.

So I want to have a conversation about what we can do from a dietary perspective or with your lifestyle to try to get things working the way that they're supposed to. You can't take a person who has a C plus microbiome as a result of their diet and lifestyle and turn it into an a minus with a probiotic.

You can't do that, right? You can take the C plus, and maybe if you're lucky, you turned it into a B minus. So you're only getting a little bit of wiggle with the probiotics. After pill, there's no magic pill. And so even though we want it, you know, even though we want it and it's so sexy, um, it doesn't work that way.

After dynam lifestyle, the first thing that I would consider would be actually pre biotic, uh, pre P R E biotic, which is essentially soluble fiber. Soluble fiber allows us to feed an energize the healthy microbes that live inside of you. We are selecting for the right antiinflammatory microbes. And then what happens is they reward us by taking that fiber and transforming it into short chain fatty acids that have healing effects throughout the entire body.

And I wrote an entire chapter about short chain fatty acids, my book, because I'm so obsessed with them. So that would be number two. And the reason why it's number two for me. Is because it doesn't matter who you are. It could be, you could be me, we could have radically different, radically different microbiome, but the, the effect that you're going to get from the prebiotic is going to be beneficial to both of us because we are selecting for healthy microbes.

I would make probiotics number three.

(5 mins, 2018) Why we need to talk about PREbiotics
(7 mins, 2018) Do You Need A Probiotic?
(42 mins, 2020) Prebiotics, Postbiotics & Using Dietary Fiber For Fuel
Dr McDougall: Is Milk Yogurt A Good Probiotic?

(2005) Beneficial Bowel Bacteria — Our Neglected Friends has an interesting section:

Dairy as a Probiotic Source

The best known examples of food with probiotics are yogurts containing lactic acid-producing bacteria, called Lactobacillus bulgaricus.  These organisms are non-toxic and survive passage through the intestine.  However, they cannot live and reproduce in the colon (they do not colonize the colon); therefore, they must be ingested regularly for any health promoting properties to persist.  I do not recommend yogurt as a source of friendly bacteria for two reasons. First, these bacteria’s beneficial effects have not been conclusively proven.15  More importantly, yogurt brings with it all the negative qualities of dairy products: high in fat and cholesterol, allergy producing dairy proteins, and infection with harmful viruses and bacteria. (See my May 2003 newsletter article Marketing Milk and Disease.)  Acidophilus milk is made by culturing milk with Lactobacillus acidophilus bacteria and has similar drawbacks.16   Any benefits provided by any species of Lactobacillus can be obtained much more safely and effectively in supplement forms (pills), avoiding the health risks of dairy products.

Dr McDougall has a 43-min presentation: Marketing Milk and Disease (2012) explaining why he doesn't recommend dairy products.

Prebiotics
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