Excess dietary fat increases risk of cancer. Rouleaux formation causes tissue hypoxia. Excess omega 3 supplements can potentially cause immune suppression. Excess dietary fat can lead to insulin resistance. Insulin resistance causes hyperinsulinemia. Hyperinsulinemia leads to elevation of ILGF (Insulin Like Growth Factor). Elevated insulin & ILGF cause activation of mTOR.

"Yes. Warburg's work has never been contradicted. McDougall agrees with that. I read his biography by Hans Krebs. The closer one looks at the metabolic theory, the more impressive it gets. What causes tissue hypoxia? High fat, high sodium. What causes mitochondrial dysfunction? Hypoxia. High fat even without hypoxia. Mito dysfunction leads to increased ROS. ROS bind with DNA on guanine, and this leads to DNA strand breaks. This can cause mutations. Hypoxia is what gets the ball rolling. Hypoxia activates HIF (Hypoxia Inducible Factor). Hexokinase 2 attaches to the mitochondria to prevent apoptosis. HK2 vacuums up glucose. The cancer cell is transformed into a dedifferentiated, primitive cell: like an anaerobic bacteria."

"Warburg effect is cancer cell converting glucose to lactate (anaerobic like metabolism). Reverse Warburg effect is cancer cell inducing the adjacent fibroblast (Cancer Associated Fibroblast = CAF) to convert glucose to lactate; and to send lactate & ketone bodies to the cancer cell; ie. the cancer cell is a "parasite" to the CAF. Reverse Warburg effect was described by Michael Lisanti in 2009. Reverse Warburg effect is also called metabolic coupling of cancer cells and tumor stromal cells."

Tripping Over The Truth (288 pages, 2019) by Travis Christofferson is a very good book. Great explanation of the metabolic theory of cancer. Great refutation of the somatic mutation theory of cancer. That's very important for understanding cancer.

"Chris Wark is a survivor of stage 3 colon cancer for 19 years. Book is 365 pages. 1 page per day of advice & inspiration for cancer patients. A good bathroom book."